What do Immunologists say about the COVID-19 Vaccines?

Progressive Commentary Hour – Dr. Jessica Rose  We are being lied to.  Dr. Jessica Rose is an immunologist and molecular biologist who has specialized in computational biology and the bio-mechanisms behind pathogenic infections. Her research and publications include investigating hepatitis B, cytomegalovirus, HIV, and anthrax. Dr. Rose is a graduate of the University of Newfoundland and Labrador, and received her doctorate from Bar Illan University in Israel. Dr Rose has now written and co-authored several important papers analyzing the data of Covid-19 vaccine injuries and deaths reported in the Centers for Disease Control’s Vaccine Adverse Events Reporting System  or VAERS. She also has a paper pending publication co-authored with Dr. Peter McCullough who will be guest on the program on Friday. 

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Strong antibody response correlates w/ more SEVERE clinical disease while strong T-cell response is linked w/ LESS severe disease. CD8 T-cells => signature of successful protective immunity. Note: CD8 T cells have the HIGHEST levels of vitamin D receptor compared with other major immune cells.
 

"Interview with Dr. Dan Stock on Antibody Dependent Enhancement, Vitamin D".  One extrapolation of this good interview, in layman's language, is:  The immune system has only some many resources for T-cell, B-cell antibody and so forth generation. The jab, after some prior spike antibody protection has been developed, triggers spike generation in parts unknown throughout in the body. The immune system is tricked into believing the spike-related infection has gotten past it's foothold in the body, and it's now dealing with a systemic infection. So it redirects all its resources away from its background T-cell and antibody work to the generation of this one spike-specific antibody to deal with this systemic presence of the spike. And in this redirection of resources, all the latent viruses and bacteria that were being held in check start taking off, and and latent diseases and cancers start activating/reactivating in the body. Then to compound the problem, no matter how much the immune system works to suppress this misconstrued systemic infection, the mRNA (or DNA for J&J) just keeps pumping out more spike in parts unknown in the body, keeping the immune system consumed with this antibody production and away from its general background work. And especially after the 2nd jab and each booster, the researchers pat themselves on the back at the "really robust" antibody response they're getting?!  T-cells, not antibodies, are the real Covid super stars and solve the SARS-CoV-2 problem much more elegantly.
 

This article by a vaccinologist details the qualities of a competent CD8+T-cell response: What are the roles of antibodies versus a durable, high quality T-cell response in protective immunity against SARS-CoV-2 (https://www.sciencedirect.com/science/article/pii/S2590136220300231#) However, he doesn't explain that ALL the qualities of CD8+T-cells described above DEPEND on sufficient (above 40ng/mL, ideally 50ng/mL) vitamin D blood levels.  After all, CD8+T-cells have the HIGHEST amount of the vitamin D receptor of all immune system cells (ask me for references if interested).
 
some articles about T-cell immunity and Covid:
 
1. Potent SARS-CoV-2-Specific T Cell Immunity and Low Anaphylatoxin Levels Correlate With Mild Disease Progression in COVID-19 Patients
 
2. What are the roles of antibodies versus a durable, high quality T-cell response in protective immunity against SARS-CoV-2?
 
3.  T-cells really are the superstars in fighting COVID-19 - but why are some of us so poor at making them?

4. CD8T cells specific for an immunodominant SARS- CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses

"Our findings demonstrate the basis of selective T cell cross-reactivity for an immunodominant SARS-CoV-2 epitope and its homologs from seasonal coronaviruses, suggesting long-lasting protective immunity"
 
 
5. Vitamin D Receptor Signals Regulate Effector and Memory CD8 T Cell Responses to Infections in Mice
Results: The absence of vitamin D signals significantly restricted (P ≤ 0.05) breadth of the antigen-specific CD8 T cell effector and memory repertoire
 
 
6. (from 2011):
 
The team found that T-cells, which are white blood cells that play a central role in immunity, release a protein called interferon-g that triggers communication between cells and directs infected immune cells to attack the invading tuberculosis bacteria. However, this activation requires sufficient levels of vitamin D to be effective.
 
7.  SARS-CoV-2 genome-wide mapping of CD8 T cell recognition reveals strong immunodominance and substantial CD8 T cell activation in COVID-19 patients
 
8. CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis
Exactly how sunlight increases the number of CD8+ T cells is unclear, but the effect is probably mediated at least in part by vitamin D because (1) among cells of the immune system, activated CD8+ T cells express the highest concentrations of the vitamin D receptor [78]; (2) vitamin D increases the mitogen-induced proliferation of CD8+ T cells and decreases the CD4/CD8 ratio in bovine peripheral blood mononuclear cells in vitro [79]; (3) vitamin D administration increases the CD8+ T cell count [80]; (4) vitamin D deficiency is associated with a decreased proportion of CD8+ T cells and increased CD4/CD8 ratio 
 
 
There's more in this thread:
 
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From  Stephanie Seneff, Senior Research Scientist, MIT Computer Science and Artificial Intelligence Laboratory
 
What I have zeroed in on recently re the MRNA vaccines is that they have done a fantastic job of "humanizing" the RNA such that the vaccine-infected cells do not pick up any signal that there is a viral invasion.  As a consequence, they fail to launch the interferon alpha cascade that normally triggers massive expansion of cytotoxic CD8+ T cells.

Normally, after the infection subsides, there is a strong collection of memory T cells that have long-lasting remembrance of the infection,
which helps them immediately launch a response to a new infection of the same virus.

Vaccines in general have a hard time getting the T cells to remember the event, but the mRNA vaccines are especially flawed in this respect.

T cell memory lasts 17 years whereas antibody memory only lasts a few months.
 
This is a very useful paper re vaccines, infections and T cells:
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2212878/
Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection
 
Results
 Direct action of IFN-I on antigen-specific CD8 T cells is critical for their expansion after viral infection

These mRNA vaccines not only don't elicit an interferon response, but they ACTIVELY SUPPRESS the response to interferon alpha by suppressing a
protein called IRF9 that is critical for triggering the upregulation of a whole bunch of proteins involved in controlling viral proliferation. They suppress this response GENERICALLY, which is why they cause reactivation of latent viruses producing Bell's palsy and shingles.

ADE and pathogenic priming are not the same thing, but I have never understood the discussions for exactly what makes them different. Maybe someone else knows that?

Sasha Grams on Antibody Dependent Enhancement

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Below by Mike Alexander A layperson's Studied Interpretation of an Immunological System
 
The COVID vaccine is a total decimation of T-cells. Firstly the thymus is getting destroyed. After all, it's picking up the damaging spike and mRNA of the vaccine from the bloodstream just like rest of the circulatory system is. That's where T-cells mature to their final forms from what the bone marrow puts out. (If I'm getting this right?) And it's already done it's main work in childhood, and slowly turning into fat post-teen years. Wipe that out, no more new lineage. And the new T-cells the adult body makes comes mostly from existing T-cells replicating rather than the thymus (is that right?), and they're getting wiped out by the damaging spike and mRNA of the vaccine in the bloodstram too. It couldn't be a more complete collapse. This is horrendous. Enough people just have enough T-cells and remaining thymus that you can vaccinate a million people and it isn't particular notice at first. If they had done a thorough blood analysis on each participant in the first stage trials, it would have stopped right there.
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Also on T-cells, a very laymens website maybe that I only touched on is "ask-a-biologist" youtube and website. it's an Arizona state university thing. It's very kids level though, but more thorough than you might expect! One page I found useful was "T-cells | Ask A Biologist" at
From there you can explore other items of the immune system.
Also if you want a very heart-warming video distraction, try this one of theirs "Viral Attack (The Movie)" -
Not meaty, just heart-warming is all! A nice distraction from the horror!
 
Who knew we'd all have to become at least somewhat versed in this stuff, but covid CDC FDA etc requires us to.   You commonly hear or see that T-cells come from the bone marrow, but no. The bone marrow makes what you might say T-cell eggs (progenitor cells), and those eggs go on to the thymus to be developed (incubated) into final T cells. And most of that occurs pre-puberty. Who knew! That's what I meant by lineage - no new lineage after puberity. (lineage is maybe not quite the right word.) And any further T-cells come from those now-made T-cells replicating on their own. The thymus gradually starts turning to fat in the post-puberty years, and by old age is nothing. In adulthood, what's remaining of the declining thymus is still doing some new lineage, but it's more and more the replication from existing T-cells than from new egg hatching(!).
 
I'm just doing google searches with various wordings and staying mostly on the 1st page or so of results. (a desktop page, I'm not very cell phone oriented, it never got incorporated into my DNA.) A good search here is "where are T-cells made". The ask-a-biologist page is always there, and that's surprisingly detailed for its kids-level look. Look at that page. Also while there, search for the word copy to see the reference on where more cells come from. Another good search is "where do T-cells come from in adults". That shows another good ncbi/gov website hit - Generation of lymphocytes in bone marrow and thymus", where it said more plainly that in adulthood, the T-cells come more and more from replication of existing T-cells rather than from the thymus (1st para).
Here's those 2 pages:
https://www.ncbi.nlm.nih.gov/books/NBK27123/   (particularly 1st paragraph on replication).
https://askabiologist.asu.edu/t-cell    (see right sidebar too for other immune stuff)
https://en.wikipedia.org/wiki/T_cell   (of course, you can't leave out wikipedia!, and it's good to see concurring info multiple places)
Also just a plain search on "thymus", lot of good hits on 1st page.
 
And then on the redirection of the immune system, if you missed my other reference of the Dan Stock interview
1st 10 minutes is the crux, whole thing decent. There he talks about how the immune system prioritizes systemwide antibody production over T-cells when infection gets out of its control. But honestly, I can't find a search result to back that up right now, so I'm beginning to wonder. Maybe I know just enough to be too dangerous now. 
 
Something else on that T-cell ask-a-biologist page that was new me is the whole lymphatic system. We all know about lymph nodes and such, but the whole interconnected system was new to me. It's a parallel system to the circulatory system, but without a heartbeat to move its fluids around. It requires muscle contractions and bodily motion to move the fluids around! So you have to get out and walk and exercise to keep the lymphatic system fluids going! Just an interesting tidbit that I suspect isn't well known.I got that from basic searches on it "lymphatic system requires bodily motion".
here's one of the hits from that