Borg Woo - Explorers' Guide To SciFi World Are COVID Jabbed Arms' Injection Sites Magnetic?
Superparamagnetic nanoparticle delivery of DNA vaccine 2014
The efficiency of delivery of DNA vaccines is often relatively low compared to protein vaccines. The use of superparamagnetic iron oxide nanoparticles (SPIONs) to deliver genes via magnetofection shows promise in improving the efficiency of gene delivery both in vitro and in vivo. In particular, the duration for gene transfection especially for in vitro application can be significantly reduced by magnetofection compared to the time required to achieve high gene transfection with standard protocols.
Magnetic Nanovectors for the Development of DNA Blood-Stage Malaria Vaccines 2017
Fatin M Nawwab Al-Deen 1 , Sue D Xiang 2 , Charles Ma 3 , Kirsty Wilson 4 , Ross L Coppel 5 , Cordelia Selomulya 6 , Magdalena Plebanski 7
DNA vaccines offer cost, flexibility, and stability advantages, but administered alone have limited immunogenicity. Previously, we identified optimal configurations of magnetic vectors comprising superparamagnetic iron oxide nanoparticles (SPIONs), polyethylenimine (PEI), and hyaluronic acid (HA) to deliver malaria DNA encoding Plasmodium yoelii (Py) merozoite surface protein MSP119 (SPIONs/PEI/DNA + HA gene complex) to dendritic cells and transfect them with high efficiency in vitro. Herein, we evaluate their immunogenicity in vivo by administering these potential vaccine complexes into BALB/c mice.
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